北京大学医学部病理系（暨北京大学第三医院病理科）副主任，主任医师，副教授，博士生导师。毕业于香港中文大学医学院病理系，获博士学位。曾于2016年在美国华盛顿大学做访问学者1年。现任中国抗癌协会肿瘤病理专业委员会脑胶质瘤协作组副组长，北京医学会病理学分会神经病理学组副组长，中华医学会病理学分会神经病理学组委员等职。擅长系统病理诊断及神经肿瘤的病理诊断、分子标志物筛选及机制研究。建立了国内第一个基于Nanostring法的髓母细胞瘤分子分型平台，申请国家专利3项。主持国家自然科学基金项目3项，北京市自然科学基金面上项目1项,横向课题1项。在Cancer letters, Cancer Science 和 International J. of Cancer等杂志发表SCI及核心期刊论文30余篇。

主要代表作：

1. Liangyi Zhu#, Ying Yang#, Haishuang Li#, Luzheng Xu, Huanyu You, Yantao Liu, Zongran Liu, Xiaodan Liu, Danfeng Zheng Juntao Bie4, Jiaqi Li, Chao Song, Bao Yang*, Jianyuan Luo*, Qing Chang*. Exosomal microRNAs induce tumor-associated macrophages via PPARγ during tumor progression in SHH medulloblastoma. Cancer letters 535 (2022) 215630.

2. Liang-Yi Zhu, Xiao-Yu Wu, Hai-Shuang Li, Xiao-Dan Liu, Dan-Feng Zheng, Bao Yang, Jing Zhang, Qing Chang*. Aggressive Medulloblastoma-Derived Exosomal miRNAs Promote In Vitro Invasion and Migration of Tumor Cells Via Ras/MAPK Pathway. Journal of Neuropathology & Experimental Neurology , 2020;79(7):734-745

3. Li N, Wu Y, Zhu L, Huang Y, Liu Z, Shi M, Soltys D, Zhang J*, Chang Q*. Extracellular microvesicles-derived from microglia treated with unaggregated α-synuclein attenuate mitochondrial fission and toxicity-induced by Parkinsonian toxin MPP. Biochem Biophys Res Commun. 2019;517(4):642-647.

4. Yong-Xiao Li , Zhe-Wei Yu, Tao Jiang, Li-Wei Shao, Na Li, Yu-Feng Wu, Yan Liu1, Chen Zheng, Yi-Lin He, Ming Zhang, Guan-Jun Yue, Dan-Feng Zheng, Xue-Ling Qi, Min Ding, Yan-Feng Zhong, Jing Zhang, Chang Q*. SNCA, a novel diagnostic marker for Group 4 medulloblastomas，can inhibit tumor invasion and induce apoptosis. Cancer Sci. 2018;109(4):1263-1275.Cancer Sci. 2018;109(4):1263-1275.

5. Li Y, Jiang T, Shao L, Liu Y, Zheng C, Zhong Y, Zhang J, Chang Q*. Mir-449a, a potential diagnostic biomarker for WNT group of medulloblastoma. J Neurooncol. 2016（129):423-31.

6. Shao LW, Pan Y, Qi XL, Li YX, Ma XL, Yi WN, Zhang J, Zhong YF, Chang Q*. ATRX loss in adult supratentorial diffuse astrocytomas correlates with p53 over expression and IDH1 mutation and predicts better outcome in p53 accumulated patients. Histology & Histopathology. 2016 (31):103-114.

7. Chang Q, Chen ZS, You JF, McNutt MA, Zhang T, Han ZH, Zhang XY, Gong EC, Gu J. All–trans - Retinoic Acid Induces Cell Growth Arrest in a Human Medulloblastoma Cell Line. J Neuro-Oncol. 2007 (84):263-267.

8. Chang Q, Pang JC, Li KKW, Poon WS, Zhou LF, Kong X, Ng HK. Promoter hypermethylation profile of RASSF1A, FHIT and sFRP1 in intracranial primitive neuroectodermal tumors. Hum Pathol. 2005 ;36(12):1265-72

9. Pang JC, Chang Q, Chung YF, Teo JG, Poon WS, Zhou LF, Kong X, Ng HK. Epigenetic inactivation of DLC-1 in supratentorial primitive neuroectodermal tumor. Hum Pathol. 2005 (1):36-43

10. Angela B.Y. Hui, Hirokuni Takano, Kwok-Wai Lo, Wen-Lin Kuo, Cleo N.Y. Lam, Carol Y.K.Tong, Qing Chang, Joe W. Gray, Ho-Keung Ng. Identification of a Novel Homozygous Deletion Region at 6q23.1 in medulloblastomas using high-resolution array comparative genomic hybridization analysis. Clinical Cancer Research 2005(11):4707-4716.

11. Chang Q, Pang JC, Li J, Hu LD, Kong XY, Ng HK. Molecular analysis of PinX1 in medulloblastomas. International Journal of Cancer 2004 (109):309-314.

12. Chang Q, To KF, Hui EP, Chan KW, Lai FMM. Primary nasal type NK/T lymphoma of the oral cavity with relapses and long survival. Oral Oncology EXTRA 2004(40):36-38.